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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6816 | DASA-58 | PKM | |
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. | |||
T8363 | DL-Serine | PKM | |
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. | |||
T62758 | PKM2 activator 2 | PKM | |
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol... | |||
T7214 | TEPP-46 | ML265 | PKM |
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. . | |||
T15362 | FX-11 | LDHA Inhibitor FX11 | Dehydrogenase |
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce... | |||
T70665 | PF-06284674 | ||
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator. | |||
T71867 | PKM2 inhibitor 2825-0090 | ||
PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo. | |||
T16837 | SAICAR | Others | |
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM). | |||
T68986 | ZINC08383544 | ||
ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor. | |||
T60581 | Alkannin | ||
Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1]. | |||
T70418 | TLN-232 | ||
TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic ... | |||
T73525 | ML202 | ||
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), enhancing the cooperativity of phosphoenolpyruvate (PEP) binding, with negligible effect on adenosine diphosphate (ADP) binding. |